What Are the Three Major Buffer Systems of the Body and How Do They Work?

By K Balaji|Updated : November 7th, 2022

The three major buffer systems of the body are carbonic acid bicarbonate buffer system is made of carbonic acid, phosphate buffer system is important to buffer the intracellular and renal tubular fluid and protein buffer system binds to hydroxyl and hydrogen ions.

Buffer system

  1. A solution which can survive pH variations is referred to as a buffer.
  2. The inclusion of basic or acidic components is the cause.
  3. Alkaline buffer solutions and acidic buffer solutions are the two main categories for buffer solutions.

Carbonic acid bicarbonate buffer system:

  1. Carbonic acid is the main component of the carbonic acid bicarbonate buffer system.
  2. They are weak acids in which the bicarbonate anion serves as their conjugate base.

Phosphate buffer system:

  1. It is not required as a buffer for extracellular fluid.
  2. It is crucial for preserving intracellular fluids and renal tubular fluid.
  3. when the buffer system is given a powerful base, such NaOH.
  4. The H2PO4 buffers OH- to form more HPO4 + H2O

Protein buffer system:

  1. Every protein has the capacity to function as a buffer.
  2. Amino acids make up proteins.
  3. It includes carboxyl groups and negatively and positively charged amino groups.
  4. Hydrogen and hydroxyl ions can be bound by these molecules charged areas.
  5. so serve as buffers.


What Are the Three Major Buffer Systems of the Body and How Do They Work?

The body's three main buffer systems are carbonic acid Protein buffer system binds to hydroxyl and hydrogen ions, phosphate buffer system helps to buffer intracellular and renal tubular fluid, and bicarbonate buffer system is formed of carbonic acid.

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