Short Notes on DARZEN REACTION
In the darzen reaction the condensation of a carbonyl compound with an α-haloester takes place in presence of base which results in the formation of an α-β epoxy ester.
General Reaction -
Reaction Mechanism -
Step-1: This step involves the formation of enolate of α-halo ester followed by the attack at the electrophilic carbonyl carbon.
Step-2: It involves the elimination of halide ion by the intramolecular attack of alkoxide ion by SN2 mechanism, which results in the formation of α-β epoxy ester.
Stereochemistry: The attacking alkoxide group and leaving group must be anti-to each other.
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