CSIR NET Life Science: Short Notes on Origin of Life - Oparin and Haldane Hypothesis

By Neetesh Tiwari|Updated : August 1st, 2021

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Are you looking for some short and reliable notes during your CSIR-NET preparations? Then, you have come to a perfect place!

Candidates preparing for their CSIR NET exam might need to get some short study notes and strategies to apply while preparing for the key exam of their life. At this point, We at BYJU'S Exam Prep come up with short notes on the Origin of Life - Oparin and Haldane Hypothesis, which comes under the Evolution and behaviour section of the Life Science syllabus

This set of short notes on Origin of Life - Oparin and Haldane Hypothesis has been meticulously designed by our experienced subject-matter experts to give you the most standard set of study materials to be focused upon. In this cut-throat competitive world, students need to prepare themselves with the best study materials to help them learn and for their future. Therefore, here we are offering the best study notes that are reliable and can be used by the students during their preparations for the upcoming CSIR-NET 2022 exam.



In the early decades of the 20th century, Russian chemist Aleksandr I. Oparin (1924), and British scientist John B. S. Haldane (1929), independently envisaged that if the primitive atmosphere was reducing (as opposed to the oxygen-rich atmosphere of today), and if there was an appropriate source of energy, such as lightning or ultraviolet light from the sun, then a wide range of organic compounds might have formed.


Oparin hypothesized that the organic compounds might have undergone a reaction series resulting in simpler to more complex molecules. He proposed that the molecules formed colloidal aggregates, namely, coacervates, in an aqueous environment. These coacervates could absorb and assimilate organic compounds from the environment to utilise them, which resembles present-day metabolism. They would have evolved to different forms, eventually leading to the first lifeforms on the Earth.

Haldane coined the term prebiotic soup. Haldane's ideas about the origin of life were very similar to that of Oparin's. Haldane proposed that the primordial sea served as a vast chemical medium powered by solar energy. Since the atmosphere was oxygen (O2) free, and the combination of carbon dioxide (CO2), ammonia (NH3) and ultraviolet (UV) radiations gave rise to an aggregate of organic compounds.


The sea became a hot dilute soup containing large populations of organic compound monomers and polymers. Haldane proposed that groups of monomers and polymers acquired lipid membranes, and those further developments eventually led to the first living cells.

Miller-Urey Experiment

In 1953, Harold Urey and his student Stanley Miller test Oparin and Haldane's hypothesis. But, first, they tried to calculate the chemical constituents of the early Earth atmosphere. The basis of their experiment was that the early atmosphere was reducing. So they simulated early earth atmospheric conditions in a closed system that contained methane gas (CH4), ammonia (NH3), and hydrogen gas (H2) in a 2:1:2 ratio with water vapours (H2O) and a high temperature of 1073 K.


Miller carried out an experiment in which he passed a continuous spark discharge at 75,000 volts through a flask containing the gases identified by Urey along with water. Furthermore, this electrical current was run through the laboratory set up to simulate the catalytic source of lightning present in the early atmosphere.

After 18 days of circulating the mixture, Miller found that most of the ammonia and much of the methane had been consumed. The main gaseous products were carbon monoxide (CO) and nitrogen (N2). In addition, there was an accumulation of dark material in the water. Few of the specific constituents of this could not be identified, but it was clear that the material included a large range of organic polymers. From the results of their experiment, they found that up to 15% of the carbon in the system was inorganic compounds that had formed in the system.

This conclusion proved that organic molecules could be formed from inorganic molecules in Earth’s early atmosphere. In addition, out of the organic molecules produced, Miller and Urey showed that some of the organic compounds were amino acids necessary for living organisms. Analysis of the aqueous solution showed that the following had also been synthesized: 25 amino acids (the main ones being glycine, alanine and aspartic acid), several fatty acids, hydroxy acids and amide products.


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