Difference between COVISHIELD and COVAXIN

By Sudheer Kumar K|Updated : January 15th, 2021

Recently, the Indian Government has approved the Oxford COVID-19 vaccine, called Covishield in India, and Bharat Biotech's Covaxin have been approved for emergency use in the country. However, there has been confusion among people about which one is safe and effective. In this article, we will discuss the difference between the two vaccines in brief and their efficacy.

Difference between COVISHIELD and COVAXIN


  • The Oxford-AstraZeneca and Serum Insitute of India's COVID vaccine (also known as AZD1222 ) is called COVISHIELD.
  • It is a weakened version of a common cold virus- adenovirus- which contains the genetic material of the SARS-CoV-2 virus spike protein.
  • Once the vaccine is administered, the surface spike protein is produced in the human body allowing the immune system to be prepared to attack the virus if it affects the body in the future. 
  • The peer-reviewed studies of Phase 3 human trials of Oxford Vaccine demonstrate 70.4 per cent efficacy.
  • It is approved for emergency use in the country.


  • Covaxin (BBV152) is India's first home-grown COVID vaccine. It is developed by Bharat Biotech.
  • Covaxin is an inactivated form of the novel coronavirus. It is developed by inactivating the virus. The vaccine was produced from a viral strain that was isolated from an asymptomatic COVID-19 patient.
  • The vaccine can generate antibodies that destroy the ability of the virus to replicate. These antibodies may persist for 6-12 months
  • Phase 1 trials proved effective and safe and phase 3 trials are undergoing.


Both the vaccines are proved effective against the new COVID Strain (in UK) which is more lethal than the present COVID virus. Another significant feature of Covaxin and Covishield is that they can be stored at normal refrigeration conditions. That means they can be transported to long-distance places safely without any need for cold storage.


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